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Home page > Research > Research units > ChrOnic PAin Laboratory _ CoPaL

ChrOnic PAin Laboratory _ CoPaL

Scientific coordinator: Prof. Pierangelo Geppetti

Pierangelo Geppetti, MD

Department of Health Sciences, University of Florence

Professor of Clinical Pharmacology at the Medical School of the University of Florence 
Director of the Department of Health Sciences of the University of Florence
Chief of the Clinical Unit - Headache Center and Clinical Pharmacology, University Hospital of Careggi – Florence 
President of the Italian Society for the Study of Headaches
Editor of Physiological Reviews, Pain, Molecular Pain, The Journal of Headache and Pain, Handbook of Experimental Pharmacology
Awarded the European Research Council Advanced Grant 2019

 

Research Interest

Pierangelo Geppetti is a clinician and basic scientist studying the mechanisms and treatments of chronic pain, with a special focus on migraine and related primary headaches. Pierangelo’s lab seeks to understand the role of the feed-forward pathway which entails transient receptor potential (TRP) channels in Schwann cells and their ability to generate oxidative stress to signal chronic pain in models of inflammatory, neuropathic, cancer, and migraine pain.  The lab also seeks to discover new medicines for the treatment of chronic pain. 

 

Representative Publications

More than 360 original and review articles 
H-Index of 73 and total citations >19,000 (Scopus).

 

Review articles

Geppetti P, Veldhuis NA, Lieu T, Bunnett NW. G Protein-Coupled Receptors: Dynamic Machines for Signaling Pain and Itch. Neuron. 2015 Nov 18;88(4):635-49.

Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW. Physiol Rev. 2014 94:265-301.

Parenti A, De Logu F, Geppetti P, Benemei S. What is the evidence for the role of TRP channels in inflammatory and immune cells? Br J Pharmacol. 2016 Mar;173(6):953-69.

Nassini R, Materazzi S, Benemei S, Geppetti P. The TRPA1 channel in inflammatory and neuropathic pain and migraine. Rev Physiol Biochem Pharmacol. 2014;167:1-43.

 

Original articles

De Logu F, Li Puma S, Landini L, Portelli F, Innocenti A, de Araujo DSM, Janal MN, Patacchini R, Bunnett NW, Geppetti P, Nassini R. Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice. J Clin Invest. 2019 Dec 2;129(12):5424-5441.

 Marone IM, De Logu F, Nassini R, De Carvalho Goncalves M, Benemei S, Ferreira J, Jain P, Li Puma S, Bunnett NW, Geppetti P, Materazzi S. TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. Brain. 2018 Jul 6. doi: 10.1093

De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl'Innocenti D, Marone IM, Ferreira J, Li Puma S, Benemei S, Trevisan G, Souza Monteiro de Araújo D, Patacchini R, Bunnett NW, Geppetti P. Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice. Nat Commun. 2017 8:1887.

Trevisan G, Benemei S, Materazzi S, De Logu F, De Siena G, Fusi C, Fortes Rossato M, Marone IM, Ferreira J, Geppetti P, Nassini R. TRPA1, downstream to monocytes/macrophages and oxidative stress, mediates trigeminal neuropathic pain in mice. Brain 2016, 139:1361-77.

Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S. The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives. Br J Pharmacol. 2015 172:3397-411

Fusi C, Materazzi S, Benemei S, Coppi E, Trevisan G, Marone IM, Minocci D, De Logu F, Tuccinardi T, Di Tommaso MR, Susini T, Moneti G, Pieraccini G, Geppetti P, Nassini R. Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1. Nat Commun. 2014 8;5:5736.

The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Brain 2012  135:376-90.

Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest. 2008, 118:2574-82.

Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. Proc Natl Acad Sci U S A. 2007 104:13519-24.

Complete listing available on the University of Florence site

Lab Members 

Romina Nassini, PhD, 

Scientific Researcher

Romina Nassini is a basic scientist whose research interest focuses on the identification of new activators and inhibitors of the TRP channels and the molecular and translational aspects of these mechanisms. Romina has contributed to the identification of pathways by which inflammatory mediators signal to sensory nerves by gating receptors and channels, to cause pain in different models of cancer-related pain, including those due to the use of chemotherapeutic drugs, and models of pain due to cancer growth. More recently, Romina has contributed substantially to the identification of a novel mechanism (the TRPA1/NOX1 pathway) in Schwann cells, which, sustaining neuroinflammation, signals chronic neuropathic pain. 

73 original and review articles, 6 book chapters e 6 conference proceedings. 

H-Index 31, Total Citations = 3361 (Scopus)

Complete listing available on the University of Florence site

Francesco De Logu, PhD, 

Scientific Researcher

Francesco De Logu is a basic scientist who has opened a new area of investigation in the lab by coupling pharmacology and bio-imaging. Francesco, using unique expertise in several in vitro (molecular and cellular biology and immunohistochemistry) and in vivo (mastering complex models of diseases in mice) techniques, has markedly contributed to the understanding of the cellular and molecular basis of neuroinflammatory pathways that sustain chronic pain. Editor in Experimental Pharmacology and Drug Discovery, Frontiers in Pharmacology.

32 original and review articles, 4 book chapters.

H-Index 11, Total Citations 341  (Scopus)

Complete listing available on the University of Florence site

Other lab members

Daniel Souza Monteiro De Araujo, PhD, Research Fellow
Gaetano De Siena, PharmD, Research Fellow
Matilde Marini, BS, Research Fellow
Lorenzo Landini, PhD student 
Mustafa Titiz, BS, Research Fellow

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Pierangelo Geppetti, MD
Department of Health Sciences, University of Florence
Professor of Clinical Pharmacology at the Medical School of the University of Florence
Director of the Department of Health Sciences of the University of Florence
Chief of the Clinical Unit - Headache Center and Clinical Pharmacology, University Hospital of Careggi –
Florence
President of the Italian Society for the Study of Headaches
Editor of Physiological Reviews, Pain, Molecular Pain, The Journal of Headache and Pain, Handbook of
Experimental Pharmacology
Awarded the European Research Council Advanced Grant 2019
Research Interest
Pierangelo Geppetti is a clinician and basic scientist studying the mechanisms and treatments of chronic
pain, with a special focus on migraine and related primary headaches. Pierangelo’s lab seeks to
understand the role of the feed-forward pathway which entails transient receptor potential (TRP)
channels in Schwann cells and their ability to generate oxidative stress to signal chronic pain in models of
inflammatory, neuropathic, cancer, and migraine pain. The lab also seeks to discover new medicines for
the treatment of chronic pain.
Representative Publications
More than 360 original and review articles
H-Index of 73 and total citations >19,000 (Scopus).
Review articles
Geppetti P​ , Veldhuis NA, Lieu T, Bunnett NW. G Protein-Coupled Receptors: Dynamic Machines for
Signaling Pain and Itch. Neuron. 2015 Nov 18;88(4):635-49.
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.
Steinhoff MS, von Mentzer B, ​ Geppetti P​ , Pothoulakis C, Bunnett NW. ​ Physiol Rev. ​ 2014 94:265-301.
Parenti A, De Logu F, ​ Geppetti P​ , Benemei S. What is the evidence for the role of TRP channels in
inflammatory and immune cells? Br J Pharmacol. 2016 Mar;173(6):953-69.
Nassini R, Materazzi S, Benemei S, Geppetti P. The TRPA1 channel in inflammatory and neuropathic pain
and migraine. Rev Physiol Biochem Pharmacol. 2014;167:1-43.
Original articles
De Logu F, Li Puma S, Landini L, Portelli F, Innocenti A, de Araujo DSM, Janal MN, Patacchini R,
Bunnett NW, ​ Geppetti P​ , Nassini R. ​ Schwann cells expressing nociceptive channel TRPA1 orchestrate
ethanol-evoked neuropathic pain in mice.​ ​ J Clin Invest . ​ 2019 Dec 2;129(12):5424-5441.
Marone IM, De Logu F, Nassini R, De Carvalho Goncalves M, Benemei S, Ferreira J, Jain P, Li Puma S,
Bunnett NW, ​ Geppetti P​ , Materazzi S. TRPA1/NOX in the soma of trigeminal ganglion neurons
mediates migraine-related pain of glyceryl trinitrate in mice. ​ Brain . ​ 2018 Jul 6. doi: 10.1093
De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl'Innocenti D, Marone IM,
Ferreira J, Li Puma S, Benemei S, Trevisan G, Souza Monteiro de Araújo D, Patacchini R, Bunnett
NW, ​ Geppetti P​ . ​ Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent
neuropathic pain in mice.​ ​ Nat Commun ​ . 2017 8:1887.
Trevisan ​ G, Benemei ​ S, Materazzi ​ S, De Logu ​ F, De Siena ​ G, Fusi ​ C, Fortes Rossato ​ M, Marone ​ IM, Ferreira
J, ​ Geppetti ​ P​ , Nassini ​ R. TRPA1, downstream to monocytes/macrophages and oxidative stress, mediates
trigeminal neuropathic pain in mice. ​ Brain ​ 2016, 139:1361-77.
Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R,
Chiarugi A, Patacchini R, ​ Geppetti P​ , Benemei S. The TRPA1 channel mediates the analgesic action of
dipyrone and pyrazolone derivatives. ​ Br J Pharmacol ​ . 2015 172:3397-411
1Fusi C, Materazzi S, Benemei S, Coppi E, Trevisan G, Marone IM, Minocci D, De Logu F, Tuccinardi T, Di
Tommaso MR, Susini T, Moneti G, Pieraccini G, ​ Geppetti P​ , Nassini R. Steroidal and non-steroidal
third-generation aromatase inhibitors induce pain-like symptoms via TRPA1. ​ Nat Commun. ​ 2014 8;5:5736.
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Nassini R,
Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky
L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B,
Geppetti P​ . ​ Brain ​ 2012 135:376-90.
Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R,
Civelli M, Baraldi PG, Poole DP, Bunnett NW, ​ Geppetti P​ , Patacchini R. Cigarette smoke-induced
neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in
rodents. ​ J Clin Invest ​ . 2008, 118:2574-82.
Trevisani M​ , ​ Siemens J​ , ​ Materazzi S​ , ​ Bautista DM​ , ​ Nassini R​ , ​ Campi B​ , ​ Imamachi N​ , ​ Andrè E​ , ​ Patacchini
R​ , ​ Cottrell GS​ , ​ Gatti R​ , ​ Basbaum AI​ , ​ Bunnett NW​ , ​ Julius D​ , ​ Geppetti P​ . ​ Trevisani M​ , ​ Siemens J​ , ​ Materazzi
S​ , ​ Bautista DM​ , ​ Nassini R​ , ​ Campi B​ , ​ Imamachi N​ , ​ Andrè E​ , ​ Patacchini R​ , ​ Cottrell GS​ , ​ Gatti R​ , ​ Basbaum
AI​ , ​ Bunnett NW​ , ​ Julius D​ , ​ Geppetti P​ . ​ Proc Natl Acad Sci U S A. ​ 2007 104:13519-24.
Complete listing available on the University of Florence ​ site​ .
Lab Members
Romina Nassini​ , PhD,
Scientific Researcher
Romina Nassini is a basic scientist whose research interest focuses on the identification of new activators and
inhibitors of the TRP channels and the molecular and translational aspects of these mechanisms. Romina has
contributed to the identification of pathways by which inflammatory mediators signal to sensory nerves by
gating receptors and channels, to cause pain in different models of cancer-related pain, including those due
to the use of chemotherapeutic drugs, and models of pain due to cancer growth. More recently, Romina has
contributed substantially to the identification of a novel mechanism (the TRPA1/NOX1 pathway) in
Schwann cells, which, sustaining neuroinflammation, signals chronic neuropathic pain.
73 original and review articles, 6 book chapters e 6 conference proceedings.
H-Index 31, Total Citations = 3361 (Scopus)
Complete listing available on the University of Florence ​ site​ .
Francesco De Logu​ , PhD,
Scientific Researcher
Francesco De Logu is a basic scientist who has opened a new area of investigation in the lab by coupling
pharmacology and bio-imaging. Francesco, using unique expertise in several ​ in vitro (molecular and
cellular biology and immunohistochemistry) and ​ in vivo (mastering complex models of diseases in mice)
techniques, has markedly contributed to the understanding of the cellular and molecular basis of
neuroinflammatory pathways that sustain chronic pain. Editor in Experimental Pharmacology and Drug
Discovery, Frontiers in Pharmacology.
32 original and review articles, 4 book chapters.
H-Index 11, Total Citations 341 (Scopus)
Complete listing available on the University of Florence ​ site​ .
Other lab members
Daniel Souza Monteiro De Araujo, PhD, Research Fellow
2Gaetano De Siena, PharmD, Research Fellow
Matilde Marini, BS, Research Fellow
Lorenzo Landini, PhD student
Mustafa Titiz, BS, Research Fellow
Pierangelo Geppetti, MD
Department of Health Sciences, University of Florence
Professor of Clinical Pharmacology at the Medical School of the University of Florence
Director of the Department of Health Sciences of the University of Florence
Chief of the Clinical Unit - Headache Center and Clinical Pharmacology, University Hospital of Careggi –
Florence
President of the Italian Society for the Study of Headaches
Editor of Physiological Reviews, Pain, Molecular Pain, The Journal of Headache and Pain, Handbook of
Experimental Pharmacology
Awarded the European Research Council Advanced Grant 2019
Research Interest
Pierangelo Geppetti is a clinician and basic scientist studying the mechanisms and treatments of chronic
pain, with a special focus on migraine and related primary headaches. Pierangelo’s lab seeks to
understand the role of the feed-forward pathway which entails transient receptor potential (TRP)
channels in Schwann cells and their ability to generate oxidative stress to signal chronic pain in models of
inflammatory, neuropathic, cancer, and migraine pain. The lab also seeks to discover new medicines for
the treatment of chronic pain.
Representative Publications
More than 360 original and review articles
H-Index of 73 and total citations >19,000 (Scopus).
Review articles
Geppetti P​ , Veldhuis NA, Lieu T, Bunnett NW. G Protein-Coupled Receptors: Dynamic Machines for
Signaling Pain and Itch. Neuron. 2015 Nov 18;88(4):635-49.
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.
Steinhoff MS, von Mentzer B, ​ Geppetti P​ , Pothoulakis C, Bunnett NW. ​ Physiol Rev. ​ 2014 94:265-301.
Parenti A, De Logu F, ​ Geppetti P​ , Benemei S. What is the evidence for the role of TRP channels in
inflammatory and immune cells? Br J Pharmacol. 2016 Mar;173(6):953-69.
Nassini R, Materazzi S, Benemei S, Geppetti P. The TRPA1 channel in inflammatory and neuropathic pain
and migraine. Rev Physiol Biochem Pharmacol. 2014;167:1-43.
Original articles
De Logu F, Li Puma S, Landini L, Portelli F, Innocenti A, de Araujo DSM, Janal MN, Patacchini R,
Bunnett NW, ​ Geppetti P​ , Nassini R. ​ Schwann cells expressing nociceptive channel TRPA1 orchestrate
ethanol-evoked neuropathic pain in mice.​ ​ J Clin Invest . ​ 2019 Dec 2;129(12):5424-5441.
Marone IM, De Logu F, Nassini R, De Carvalho Goncalves M, Benemei S, Ferreira J, Jain P, Li Puma S,
Bunnett NW, ​ Geppetti P​ , Materazzi S. TRPA1/NOX in the soma of trigeminal ganglion neurons
mediates migraine-related pain of glyceryl trinitrate in mice. ​ Brain . ​ 2018 Jul 6. doi: 10.1093
De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl'Innocenti D, Marone IM,
Ferreira J, Li Puma S, Benemei S, Trevisan G, Souza Monteiro de Araújo D, Patacchini R, Bunnett
NW, ​ Geppetti P​ . ​ Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent
neuropathic pain in mice.​ ​ Nat Commun ​ . 2017 8:1887.
Trevisan ​ G, Benemei ​ S, Materazzi ​ S, De Logu ​ F, De Siena ​ G, Fusi ​ C, Fortes Rossato ​ M, Marone ​ IM, Ferreira
J, ​ Geppetti ​ P​ , Nassini ​ R. TRPA1, downstream to monocytes/macrophages and oxidative stress, mediates
trigeminal neuropathic pain in mice. ​ Brain ​ 2016, 139:1361-77.
Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R,
Chiarugi A, Patacchini R, ​ Geppetti P​ , Benemei S. The TRPA1 channel mediates the analgesic action of
dipyrone and pyrazolone derivatives. ​ Br J Pharmacol ​ . 2015 172:3397-411
1Fusi C, Materazzi S, Benemei S, Coppi E, Trevisan G, Marone IM, Minocci D, De Logu F, Tuccinardi T, Di
Tommaso MR, Susini T, Moneti G, Pieraccini G, ​ Geppetti P​ , Nassini R. Steroidal and non-steroidal
third-generation aromatase inhibitors induce pain-like symptoms via TRPA1. ​ Nat Commun. ​ 2014 8;5:5736.
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Nassini R,
Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky
L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B,
Geppetti P​ . ​ Brain ​ 2012 135:376-90.
Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R,
Civelli M, Baraldi PG, Poole DP, Bunnett NW, ​ Geppetti P​ , Patacchini R. Cigarette smoke-induced
neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in
rodents. ​ J Clin Invest ​ . 2008, 118:2574-82.
Trevisani M​ , ​ Siemens J​ , ​ Materazzi S​ , ​ Bautista DM​ , ​ Nassini R​ , ​ Campi B​ , ​ Imamachi N​ , ​ Andrè E​ , ​ Patacchini
R​ , ​ Cottrell GS​ , ​ Gatti R​ , ​ Basbaum AI​ , ​ Bunnett NW​ , ​ Julius D​ , ​ Geppetti P​ . ​ Trevisani M​ , ​ Siemens J​ , ​ Materazzi
S​ , ​ Bautista DM​ , ​ Nassini R​ , ​ Campi B​ , ​ Imamachi N​ , ​ Andrè E​ , ​ Patacchini R​ , ​ Cottrell GS​ , ​ Gatti R​ , ​ Basbaum
AI​ , ​ Bunnett NW​ , ​ Julius D​ , ​ Geppetti P​ . ​ Proc Natl Acad Sci U S A. ​ 2007 104:13519-24.
Complete listing available on the University of Florence ​ site​ .
Lab Members
Romina Nassini​ , PhD,
Scientific Researcher
Romina Nassini is a basic scientist whose research interest focuses on the identification of new activators and
inhibitors of the TRP channels and the molecular and translational aspects of these mechanisms. Romina has
contributed to the identification of pathways by which inflammatory mediators signal to sensory nerves by
gating receptors and channels, to cause pain in different models of cancer-related pain, including those due
to the use of chemotherapeutic drugs, and models of pain due to cancer growth. More recently, Romina has
contributed substantially to the identification of a novel mechanism (the TRPA1/NOX1 pathway) in
Schwann cells, which, sustaining neuroinflammation, signals chronic neuropathic pain.
73 original and review articles, 6 book chapters e 6 conference proceedings.
H-Index 31, Total Citations = 3361 (Scopus)
Complete listing available on the University of Florence ​ site​ .
Francesco De Logu​ , PhD,
Scientific Researcher
Francesco De Logu is a basic scientist who has opened a new area of investigation in the lab by coupling
pharmacology and bio-imaging. Francesco, using unique expertise in several ​ in vitro (molecular and
cellular biology and immunohistochemistry) and ​ in vivo (mastering complex models of diseases in mice)
techniques, has markedly contributed to the understanding of the cellular and molecular basis of
neuroinflammatory pathways that sustain chronic pain. Editor in Experimental Pharmacology and Drug
Discovery, Frontiers in Pharmacology.
32 original and review articles, 4 book chapters.
H-Index 11, Total Citations 341 (Scopus)
Complete listing available on the University of Florence ​ site​ .
Other lab members
Daniel Souza Monteiro De Araujo, PhD, Research Fellow
2Gaetano De Siena, PharmD, Research Fellow
Matilde Marini, BS, Research Fellow
Lorenzo Landini, PhD student
Mustafa Titiz, BS, Research Fellow
 
last update: 14-Apr-2020
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